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Support for Natural Blood Sugar Metabolism.*

Berberine is an alkaloid found in many plants, but most notably in goldenseal, Barberry, Oregon grape, and Goldthread. These plants have a long history of use in supporting our health in a variety of ways.*

Berberine can be produced from various plant parts (e.g., seed, bark, root, etc.). Enzymedica’s Berberine is unique because it is a completely renewable and sustainable product produced from the seeds of barberry.

Berberine Benefits

  • Promotes a healthy microbiome*
  • Balances intestinal function*
  • Supports cardiovascular health*
  • Helps maintain healthy blood sugar balance*

Enzymedica Berberine

  • Sustainable and preferred source of berberine from the seeds of barberry.
  • Enteric-coated to prevent self-aggregation and formation of berberine crystals that reduce absorption.

Enzymedica’s Berberine uses a targeted delivery capsule to prevent the breakdown of the capsule and early release of berberine in the stomach. This type of capsule is recommended for proper berberine supplementation. In an acidic environment berberine binds with other berberine molecules to form insoluble complexes that do not get absorbed.

Berberine Studies

Berberine has been extensively studied in clinical trials for positively influencing regular blood sugar, lipids, and hypertension.*

Recently, the Journal of Ethnopharmacology published a detailed review of the 27 clinical studies with berberine, providing clear insight into safety and efficacy.(1)*

Berberine has also been examined as a weight loss aid in two double-blind clinical trials.*

In one study, 37 men and women with metabolic syndrome were given 300 mg of berberine three times per day for three months. The body mass index (BMI) levels dropped from 31.5 to 27.4.(2)*

In another study, 500 mg of berberine three times per day caused an average of 5 pounds of weight loss over a 12-week period.(3)*

Usage & Notes

Recommended Use: One 500 mg capsule before meals with a glass of water two to three times daily.

Contains NO: gluten, milk, casein, soy, egg, artificial colors or flavors.

Enzymedica does not use ingredients produced using biotechnology.

Consult with a physician prior to use if pregnant or nursing.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Berberine and berberine-containing plants are not recommended for use during pregnancy.

Berberine may interfere with the absorption of tetracycline and related antibiotics. Berberine produces significant inhibition of CYP3A enzymes in humans. Because these enzymes metabolize most drugs, berberine may decrease the clearance of many medications thereby potentiating their effect.

Berberine-containing plants may enhance the effects of oral hypoglycemic drugs through its multitude of anti-diabetic effects. People on oral hypoglycemic drugs should monitor blood glucose levels if taking berberine. Adjustment of drug dosage may be required.


1. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015 Feb 23;161:69-81.

2. Yang, J., Yin, J., Gao, H., Xu, L., Wang, Y., and Li, M. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid. Based Complement. Altern. Med. 2012; 2012: 363845.

3. Perez-Rubio, K.G., Gonzalez-Ortiz, M., Martinez-Abundis, E., Robles-Cervantes, J.A., and Espinel-Bermudez, M.C. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab. Syndr. Relat. Disord. 2013; 11: 366–369.

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